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UAB Digital Repository of Documents 4 records found  Search took 0.01 seconds. 
1.
30 p, 744.2 KB Differential Hypothalamic-pituitary-adrenal Response to Stress among Rat Strains : Methodological Considerations and Relevance for Neuropsychiat-ric Research / Armario Garcia, Antonio (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Belda Poyato, Francisco Javier (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Gagliano, Humberto Antonio (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Fuentes, Silvia (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Molina Molina, Patricia (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Serrano Garcia, Sara (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Nadal i Alemany, Roser (Universitat Autònoma de Barcelona. Institut de Neurociències)
The hormones of the hypothalamic-pituitary-adrenal (HPA) axis, particularly glucocorti-coids (GCs), play a critical role in the behavioral and physiological consequences of exposure to stress. For this reason, numerous studies have described differences in HPA function between different rodent strains/lines obtained by genetic selection of certain characteristics not directly related to the HPA axis. [...]
2023 - 10.2174/1570159X21666221129102852
Current neuropharmacology, Vol. 21 Núm. 9 (2023) , p. 1906-1923  
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2.
18 p, 1.4 MB Experimental Models for Aging and their Potential for Novel Drug Discovery / Folch, Jaume (Universitat Rovira i Virgili. Facultat de Medicina i Ciències de la Salut) ; Busquets, Oriol (Universitat Rovira i Virgili. Facultat de Medicina i Ciències de la Salut) ; Ettcheto, Miren (Universitat Rovira i Virgili. Facultat de Medicina i Ciències de la Salut) ; Sánchez-López, Elena (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Pallàs, Mercè (Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas) ; Beas-Zarate, Carlos (Departamento de Biologia Celulary Molecular, C.U.C.B.A., Universidad de Guadalajara and Division de Neurociencias, Sierra Mojada 800, Col. Independencia, Guadalajara, Jalisco 44340, Mexico.) ; Marin, Miguel (Centro de Biotecnologia. Universidad Nacional de Loja, Av. Pío Jaramillo Alvarado y Reinaldo Espinosa, La Argelia. Loja, Ecuador.) ; Casadesus, Gemma (Department of Biological Sciences, Kent State University, Kent, OH, United States.) ; Olloquequi, Jordi (Universidad Autonoma de Chile. Facultad de Ciencias de la Salud) ; Auladell, Carme (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia) ; Camins, Antoni (Universitat de Barcelona. Departament de Farmacologia, Toxicologia i Química Terapèutica)
An interesting area of scientific research is the development of potential antiaging drugs. In order to pursue this goal, it is necessary to gather the specific knowledge about the adequate preclinical models that are available to evaluate the beneficial effects of new potential drugs. [...]
2018 - 10.2174/1570159X15666170707155345
Current neuropharmacology, Vol. 16 (december 2018) , p. 1466-1483  
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3.
24 p, 3.2 MB Neuroprotective Effects of Exercise Treatments After Injury : The Dual Role of Neurotrophic Factors / Cobianchi, Stefano (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Arbat-Plana, Ariadna (Universitat Autònoma de Barcelona. Institut de Neurociències) ; López-Álvarez, Víctor M. (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Navarro, X. (Xavier) (Xavier) (Universitat Autònoma de Barcelona. Institut de Neurociències)
Shared connections between physical activity and neuroprotection have been studied for decades, but the mechanisms underlying this effect of specific exercise were only recently brought to light. Several evidences suggest that physical activity may be a reasonable and beneficial method to improve functional recovery in both peripheral and central nerve injuries and to delay functional decay in neurodegenerative diseases. [...]
2017 - 10.2174/1570159X14666160330105132
Current neuropharmacology, Vol. 15 (may 2017) , p. 495-518  
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4.
24 p, 1.3 MB Shining Light On An mGlu5 Photoswitchable NAM : A Theoretical Perspective / Dalton, James A. R.. (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Lans, Isaias (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Rovira Algans, Xavier (Institut de Génomique Fonctionnelle) ; Malhaire, Fanny (Institut de Génomique Fonctionnelle) ; Gómez-Santacana, Xavier (Universitat Autònoma de Barcelona. Institut de Neurociències) ; Pittolo, Silvia (Institut de Bioenginyeria de Catalunya) ; Gorostiza, Pau (Institut de Bioenginyeria de Catalunya) ; Llebaria, Amadeu (Institut de Química Avançada de Catalunya) ; Goudet, Cyril (Institut de Génomique Fonctionnelle) ; Pin, Jean-Philippe (Institut de Génomique Fonctionnelle) ; Giraldo, Jesús (Universitat Autònoma de Barcelona. Institut de Neurociències)
Metabotropic glutamate receptors (mGluRs) are important drug targets because of their involvement in several neurological diseases. Among mGluRs, mGlu5 is a particularly high-profile target because its positive or negative allosteric modulation can potentially treat schizophrenia or anxiety and chronic pain, respectively. [...]
2016 - 10.2174/1570159X13666150407231417
Current neuropharmacology, Vol. 14, Num. 5 (July 2016) , p. 441-454
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